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dc.creatorMARTINS , Fernanda Maria-
dc.contributor.advisor1ORSATTI, Fábio Lera-
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/2185904879371466por
dc.date.accessioned2017-04-27T17:43:47Z-
dc.date.issued2017-02-21-
dc.identifier.citationMARTINS , Fernanda Maria. Treinamento intervalado de alta intensidade como uma estratégia de tratamento alternativo para mulheres na pós-menopausa com alto risco de diabetes Mellitus tipo 2. 2017. 97f. Dissertação (Mestrado em Educação Física) - Programa de Pós-Graduação em Educação Física, Universidade Federal do Triângulo Mineiro, Uberaba, 2017.por
dc.description.resumoA menopausa está associada às alterações na composição corporal e aumentos dos marcadores inflamatórios. A inflamação crônca causa resistência insulínica e diabetes. Em contrapartida, o treinamento combinado (COM) é capaz de prevenir ou melhorar a inflamação crônica e distúrbios metabólicos em idosos. No entanto, COM apresenta longa sessão de duração e a falta de tempo é uma razão comum para não praticar exercício. Sendo assim, o treinamento intervalado de alta intensidade (HIIT) surge como uma proposta de tratamento tempo-eficiente. Porém, existem poucos estudos que apoiam o HIIT como estratégia de intervenção em idosos, além disso, não há estudos que compararam HIIT com o COM. Portanto, o objetivo do estudo foi avaliar se o HIIT é uma estratégia tempo-eficiente, comparado ao COM, capaz promover adaptações positivas sobre a composição corporal, força muscular e marcadores inflamatórios e de resistência à insulina (RI) em mulheres na pósmenopausa (PM) com alto risco de diabetes mellitus tipo 2 (DM2). Finalizaram o estudo 16 mulheres na PM distribuídas aleatoriamente em dois grupos: COM (n=8) e HIIT (n=8). Os protocolos foram realizados três vezes por semana durante 12 semanas. A composição corporal foi determinada utilizando DEXA. Os indicadores metabólicos foram determinados por métodos automatizados e os indicadores inflamatórios por método de imunoensaio enzimático. Ambos os grupos apresentaram aumento significativo (P<0,05) no índice de massa muscular (IMM) e IL1ra. Houve diminuição significativa (P< 0,05) na glicose de jejum, HbA1c, insulina, HOMA-IR e MCP-1 (tendência para MCP-1; P = 0,056) em ambos os grupos. Os efeitos do HIIT foram estatisticamente (P> 0,05) indistinguíveis dos efeitos do COM. Apenas o COM aumentou a força muscular e o HIIT aumentou a IL-6. Foram observadas correlações negativas entre as alterações na IL-6 com as alterações na insulina e HOMA-IR (P <0,05), apenas no grupo HIIT. Os achados sugerem que protocolo HIIT é uma estratégia de tratamento tempo-eficiente alternativo capaz de promover a melhorias na massa muscular, RI e marcadores inflamatórios em mulheres na PM com alto risco de DM2.por
dc.description.abstractMenopause is associated with changes in body composition and increases in inflammatory markers. The chronic inflammation cause insulin resistance and diabetes. In contrast, combined training (COM) is able to prevent or ameliorate chronic inflammation and metabolic disorders in elderly. However, the COM presents a long period session which may be a common reason to people not do exercise due to lack of time. Thus, high-intensity interval training (HIIT) appears as a proposal for a time-efficient treatment. However, there are few randomized controlled trials to support the HIIT as alternative time-efficient treatment strategy in older adults, mainly in older women at risk for metabolic disorders. The objective was compared the effects of an adapted HIIT protocol with a COM protocol on body composition and muscle strength and insulin resistance and inflammatory markers in postmenopausal women (PW) with high risk for type 2 diabetes mellitus (TDM2). Sixteen PW high risk for TDM2 were divided into two groups: HIIT (n=8) and COM (n=8). Both groups performed a three–day-a-week routine for 12 weeks. The body composition was measured using DXA. The blood indicators were measured by automated methods and inflammatory makers were measured by markers enzyme-linked immunesorbent assay. Both groups led to significant (P < 0.05) increase in muscle mass index (MMI) and IL1ra and significant decrease in fasting glucose, HbA1c, Insulin, HOMA-IR and MCP-1 (trend to MCP-1, P = 0.056). The effects of HIIT were statistically (P > 0.05) indistinguishable from the effects of COMT. There were significant (P < 0.05) interactions of time by groups in muscle strength, indicating that only the COMT increased muscle strength. In HIIT, a significant increase in IL-6 was noted from pretraining to post-training. Negative correlations were observed between the changes in IL-6 with the changes in insulin and HOMA-IR (P < 0.05) only in HIIT group. The results of the present investigation suggest that the adapted HIIT protocol is an alternative time-efficient treatment strategy to improve muscle mass, insulin resistance, and inflammatory markers in PW with high risk for TDM2.eng
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dc.languageporpor
dc.publisherUniversidade Federal do Triângulo Mineiropor
dc.publisher.departmentInstituto de Ciências da Saúde - ICS::Curso de Graduação em Educação Físicapor
dc.publisher.countryBrasilpor
dc.publisher.initialsUFTMpor
dc.publisher.programPrograma de Pós-Graduação em Educação Físicapor
dc.relation.referencesAGERGAARD, J. et al. Light-load resistance exercise increases muscle protein synthesis and hypertrophy signaling in elderly men. Am J Physiol Endocrinol Metab, p. ajpendo 00164 2016, Oct 25 2016. ALLISON, M. K. et al. Brief Intense Stair Climbing Improves Cardiorespiratory Fitness. Med Sci Sports Exerc, v. 49, n. 2, p. 298-307, Feb 2017. ALVES, B. C.; DA SILVA, T. R.; SPRITZER, P. M. Sedentary Lifestyle and HighCarbohydrate Intake are Associated with Low-Grade Chronic Inflammation in PostMenopause: A Cross-sectional Study. Revista Brasileira de Ginecologia e Obstetrícia/RBGO Gynecology and Obstetrics, v. 38, n. 07, p. 317-324, 2016. AMERICAN COLLEGE OF SPORTS, M. et al. American College of Sports Medicine position stand. Exercise and physical activity for older adults. Med Sci Sports Exerc, v. 41, n. 7, p. 1510-30, Jul 2009. ASSOCIATION, A. D. Diagnosis and classification of diabetes mellitus. Diabetes care, v. 33, n. Supplement 1, p. S62-S69, 2010. BAHIA, L. R. et al. The costs of type 2 diabetes mellitus outpatient care in the Brazilian public health system. Value in Health, v. 14, n. 5, p. S137-S140, 2011. BALDUCCI, S. et al. Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutrition, Metabolism and Cardiovascular Diseases, v. 20, n. 8, p. 608-617, 2010. BARCELOS, L. C. et al. Low-load resistance training promotes muscular adaptation regardless of vascular occlusion, load, or volume. Eur J Appl Physiol, v. 115, n. 7, p. 1559-68, Jul 2015.44 BARRY, V. W.; CHURCH, T.; BLAIR, S. N. Effects of exercise modality on insulin resistance and functional limitation in older adults. Current Cardiovascular Risk Reports, v. 3, n. 4, p. 235-236, 2009. BATACAN, R. B. et al. Effects of high-intensity interval training on cardiometabolic health: a systematic review and meta-analysis of intervention studies. British Journal of Sports Medicine, p. bjsports-2015-095841, 2016. BERG, W. P. et al. Circumstances and consequences of falls in independent community-dwelling older adults. Age Ageing, v. 26, n. 4, p. 261-8, Jul 1997. BONORA, E. et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes care, v. 23, n. 1, p. 57-63, 2000. BOUTCHER, S. H. High-intensity intermittent exercise and fat loss. Journal of obesity, v. 2011, 2010. BRAND, J. S. et al. Age at menopause, reproductive life span, and type 2 diabetes risk: results from the EPIC-InterAct study. Diabetes Care, v. 36, n. 4, p. 1012-9, Apr 2013. CASSIDY, S. et al. High-intensity interval training: a review of its impact on glucose control and cardiometabolic health. Diabetologia, v. 60, n. 1, p. 7-23, Jan 2017. CHENG, D. Prevalence, predisposition and prevention of type II diabetes. Nutrition & metabolism, v. 2, n. 1, p. 29, 2005. CHURCH, T. S. et al. Effects of aerobic and resistance training on hemoglobin A1c levels in patients with type 2 diabetes: a randomized controlled trial. Jama, v. 304, n. 20, p. 2253-2262, 2010. CINTRA, I. D. P. et al. Métodos de inquéritos dietéticos. Cad Nutr, v. 13, n. 2, p. 11- 23, 1997. CLEASBY, M. E.; JAMIESON, P. M.; ATHERTON, P. J. Insulin resistance and sarcopenia: mechanistic links between common co-morbidities. Journal of Endocrinology, v. 229, n. 2, p. R67-R81, 2016. DA ROCHA FERNANDES, J. et al. IDF Diabetes Atlas estimates of 2014 global health expenditures on diabetes. Diabetes Research and Clinical Practice, v. 117, p. 48-54, 2016. DATASUS, I. et al. Informações de saúde: Ministério da Saúde Brasília 2012. DONATH, M. Y.; SHOELSON, S. E. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol, v. 11, n. 2, p. 98-107, Feb 2011.45 DONATH, M. Y.; SHOELSON, S. E. Type 2 diabetes as an inflammatory disease. Nature Reviews Immunology, v. 11, n. 2, p. 98-107, 2011. ELLINGSGAARD, H. et al. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat Med, v. 17, n. 11, p. 1481-9, Oct 30 2011. FORTI, L. N. et al. Load-Specific Inflammation Mediating Effects of Resistance Training in Older Persons. Journal of the American Medical Directors Association, v. 17, n. 6, p. 547-552, 2016. FRANÇA-PINTO, A. et al. Aerobic training decreases bronchial hyperresponsiveness and systemic inflammation in patients with moderate or severe asthma: a randomised controlled trial. Thorax, v. 70, n. 8, p. 732-739, 2015. FRANCESCHI, C.; CAMPISI, J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci, v. 69 Suppl 1, p. S4-9, Jun 2014. GARBER, C. E. et al. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Medicine and science in sports and exercise, v. 43, n. 7, p. 1334-1359, 2011a. ______. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Medicine & Science in Sports & Exercise, v. 43, n. 7, p. 1334-1359, 2011b. GELONEZE, B. et al. The threshold value for insulin resistance (HOMA-IR) in an admixtured population: IR in the Brazilian metabolic syndrome study. Diabetes research and clinical practice, v. 72, n. 2, p. 219-220, 2006. GIBALA, M. J.; GILLEN, J. B.; PERCIVAL, M. E. Physiological and health-related adaptations to low-volume interval training: influences of nutrition and sex. Sports Medicine, v. 44, n. 2, p. 127-137, 2014. GIBALA, M. J. et al. Physiological adaptations to low‐volume, high‐intensity interval training in health and disease. The Journal of physiology, v. 590, n. 5, p. 1077- 1084, 2012. GILLEN, J. et al. Acute high‐intensity interval exercise reduces the postprandial glucose response and prevalence of hyperglycaemia in patients with type 2 diabetes. Diabetes, Obesity and Metabolism, v. 14, n. 6, p. 575-577, 2012. GILLEN, J. B.; GIBALA, M. J. Is high-intensity interval training a time-efficient exercise strategy to improve health and fitness? Applied Physiology, Nutrition, and Metabolism, v. 39, n. 3, p. 409-412, 2013.46 GILLEN, J. B. et al. Interval training in the fed or fasted state improves body composition and muscle oxidative capacity in overweight women. Obesity (Silver Spring), v. 21, n. 11, p. 2249-55, Nov 2013. GODIN, G. et al. Differences in perceived barriers to exercise between high and low intenders: observations among different populations. American Journal of Health Promotion, v. 8, n. 4, p. 279-385, 1994. GROSSMANN, V. et al. Profile of the Immune and Inflammatory Response in Individuals With Prediabetes and Type 2 Diabetes. Diabetes Care, v. 38, n. 7, p. 1356-64, Jul 2015. HARTZ, A.; HE, T.; RIMM, A. Comparison of adiposity measures as risk factors in postmenopausal women. J Clin Endocrinol Metab, v. 97, n. 1, p. 227-33, Jan 2012. HERDER, C. et al. Chemokines as risk factors for type 2 diabetes: results from the MONICA/KORA Augsburg study, 1984–2002. Diabetologia, v. 49, n. 5, p. 921, 2006. INSTITUTO BRASILEIRO DE GEOGRAFIA, E. Pesquisa Nacional de Saúde 2013: percepção do estado de saúde, estilos de vida e doenças crônicas: Instituto Brasileiro de Geografia e Estatística Rio de Janeiro 2014. JELLEYMAN, C. et al. The effects of high-intensity interval training on glucose regulation and insulin resistance: a meta-analysis. Obes Rev, v. 16, n. 11, p. 942-61, Nov 2015. KAMEL, H. K.; MAAS, D.; DUTHIE JR, E. H. Role of hormones in the pathogenesis and management of sarcopenia. Drugs & aging, v. 19, n. 11, p. 865-877, 2002. KARSTOFT, K.; PEDERSEN, B. K. Exercise and type 2 diabetes: focus on metabolism and inflammation. Immunology and cell biology, 2015. KARVONEN, M. J.; KENTALA, E.; MUSTALA, O. The effects of training on heart rate; a longitudinal study. Annales medicinae experimentalis et biologiae Fenniae, 1957. p.307. KAVOURAS, S. A. et al. Physical activity, obesity status, and glycemic control: the ATTICA study. Medicine and science in sports and exercise, v. 39, n. 4, p. 606, 2007. KNUDSEN, S. H.; PEDERSEN, B. K. Targeting inflammation through a physical active lifestyle and pharmaceuticals for the treatment of type 2 diabetes. Current Diabetes Reports, v. 15, n. 10, p. 82, 2015. KORKIAKANGAS, E. E.; ALAHUHTA, M. A.; LAITINEN, J. H. Barriers to regular exercise among adults at high risk or diagnosed with type 2 diabetes: a systematic review. Health Promotion International, p. dap031, 2009.47 LARSEN, C. M. et al. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med, v. 356, n. 15, p. 1517-26, Apr 12 2007. LIM, E. L. et al. Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia, v. 54, n. 10, p. 2506-14, Oct 2011. LISKO, I. et al. Inflammation, adiposity, and mortality in the oldest old. Rejuvenation Res, v. 15, n. 5, p. 445-52, Oct 2012. LITTLE, J. P. et al. Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes. Journal of applied physiology, v. 111, n. 6, p. 1554-1560, 2011. MALERBI, D. A.; FRANCO, L. J. Multicenter study of the prevalence of diabetes mellitus and impaired glucose tolerance in the urban Brazilian population aged 30–69 yr. Diabetes care, v. 15, n. 11, p. 1509-1516, 1992. MAVROS, Y. et al. Reductions in C-reactive protein in older adults with type 2 diabetes are related to improvements in body composition following a randomized controlled trial of resistance training. J Cachexia Sarcopenia Muscle, v. 5, n. 2, p. 111-20, Jun 2014. ORSATTI, F. L. et al. Muscle mass gain after resistance training is inversely correlated with trunk adiposity gain in postmenopausal women. The Journal of Strength & Conditioning Research, v. 26, n. 8, p. 2130-2139, 2012. PEDERSEN, B. K. Muscle as a secretory organ. Comprehensive Physiology, 2013. PEDERSEN, B. K.; FEBBRAIO, M. A. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol, v. 8, n. 8, p. 457-65, Aug 2012. PEHRSSON, P. et al. USDA's national food and nutrient analysis program: food sampling. Journal of Food Composition and Analysis, v. 13, n. 4, p. 379-389, 2000. PICHE, M. E. et al. Relation of high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-alpha, and fibrinogen to abdominal adipose tissue, blood pressure, and cholesterol and triglyceride levels in healthy postmenopausal women. Am J Cardiol, v. 96, n. 1, p. 92-7, Jul 01 2005. PITSAVOS, C. et al. Association Between Low-Grade Systemic Inflammation and Type 2 Diabetes Mellitus Among Men and Women from the ATTICA Study. Rev Diabet Stud, v. 4, n. 2, p. 98-104, Summer 2007. RACIL, G. et al. Plyometric exercise combined with high-intensity interval training improves metabolic abnormalities in young obese females more so than interval training alone. Appl Physiol Nutr Metab, v. 41, n. 1, p. 103-9, Jan 2016.48 RICHARDSON, A. J. et al. Similar Inflammatory Responses following Sprint Interval Training Performed in Hypoxia and Normoxia. Front Physiol, v. 7, p. 332, 2016. ROGLIC, G.; UNWIN, N. Mortality attributable to diabetes: estimates for the year 2010. Diabetes research and clinical practice, v. 87, n. 1, p. 15-19, 2010. ROSENBERG, D. E. et al. Assessment of sedentary behavior with the International Physical Activity Questionnaire. Journal of physical activity & health, v. 5, p. S30, 2008. SEO, D.-I. et al. 12 weeks of combined exercise is better than aerobic exercise for increasing growth hormone in middle-aged women. International journal of sport nutrition, v. 20, n. 1, p. 21, 2010. SHIROMA, E. J. et al. Strength Training and the Risk of Type 2 Diabetes and Cardiovascular Disease. Medicine and science in sports and exercise, 2016. SHOELSON, S. E.; LEE, J.; GOLDFINE, A. B. Inflammation and insulin resistance. The Journal of clinical investigation, v. 116, n. 7, p. 1793-1801, 2006. SLENTZ, C. A. et al. Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT. Am J Physiol Endocrinol Metab, v. 301, n. 5, p. E1033-9, Nov 2011. SOCIEDADE BARSILEIRA DE DIABETES, S. Diretrizes da Sociedade Brasileira de Diabetes 2014-2015. São Paulo, 2015. STRATTON, I. M. et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ, v. 321, n. 7258, p. 405-12, Aug 12 2000. THOMPSON, W. R. Now trending: worldwide survey of fitness trends for 2014. ACSM Health Fitness J, v. 17, n. 6, p. 10-20, 2013. TOMELERI, C. M. et al. Resistance training improves inflammatory level, lipid and glycemic profiles in obese older women: A randomized controlled trial. Exp Gerontol, v. 84, p. 80-87, Nov 2016. TOTH, M. et al. Effect of menopausal status on body composition and abdominal fat distribution. International journal of obesity, v. 24, n. 2, p. 226-231, 2000. TROST, S. G. et al. Correlates of adults' participation in physical activity: review and update. Medicine and science in sports and exercise, v. 34, n. 12, p. 1996-2001, 2002. UTTER, A. C. et al. Validation of the Adult OMNI Scale of perceived exertion for walking/running exercise. Medicine and science in sports and exercise, v. 36, n. 10, p. 1776-1780, 2004.49 VISSER, M. et al. Relationship of interleukin-6 and tumor necrosis factor-α with muscle mass and muscle strength in elderly men and women The Health ABC Study. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, v. 57, n. 5, p. M326-M332, 2002. WORLD HEALTH ORGANIZATION, W. Research on the menopause. WHO Technical Report Series, n. 670, 1981. ZHANG, C. et al. Abdominal obesity and the risk of all-cause, cardiovascular, and cancer mortality: sixteen years of follow-up in US women. Circulation, v. 117, n. 13, p. 1658-67, Apr 1 2008por
dc.rightsAcesso Abertopor
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.subjectExercício Físicopor
dc.subjectHemoglobina Glicadapor
dc.subjectInflamaçãopor
dc.subjectPósmenopausapor
dc.subjectPhysical Exerciseeng
dc.subjectGlycated Hemoglobineng
dc.subjectInflammationeng
dc.subjectPostmenopauseeng
dc.subject.cnpqEducação Físicapor
dc.titleTreinamento intervalado de alta intensidade como uma estratégia de tratamento alternativo para mulheres na pós-menopausa com alto risco de diabetes Mellitus tipo 2por
dc.typeDissertaçãopor
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