http://bdtd.uftm.edu.br/handle/tede/1 Dissertações e Teses digitais organizadas por programa de pós-graduação Fri, 06 Nov 2026 19:15:31 GMT 2026-11-06T19:15:31Z http://bdtd.uftm.edu.br/handle/123456789/2185 Título: Avaliação da eficácia da vacina de células dendríticas sobre células tumorais de próstata humana (PC3) in vitro Abstract: Prostate cancer is the second most common type of cancer in men worldwide, and in many cases, after conventional treatments, the tumor recurs in an androgenindependent, aggressive, and resistant form, which reduces the life expectancy of patients. The aim of this study was to verify, through a systematic review of preclinical studies, the details of the treatment of dendritic cell immunotherapy for prostate cancer, in addition to performing an in vitro experiment to verify the responses of prostate tumor cells (PC3) in co-culture with dendritic cells. For this, co-culture was performed with combinations of PC-3 cells, dendritic cells (DCs) differentiated from cells obtained from the peripheral blood of healthy donors and lymphocytes also obtained from the peripheral blood of donors. The activation of lymphocytes from the DC vaccine is related to satisfactory clinical results in combined or non-combined therapies. The systematic review was produced from the selection of articles that included eligible criteria such as publication details, preparation of DCs and details and evaluation of the treatment. The experimental study evaluated the cytokines IL-12, IL-10, IL-4, IL- 17, TNF-a and IFN-y, from the ELISA method together with the evaluation of the migration and cell viability of PC3, DC and isolated lymphocytes and their possible combinations. Among the results of the study, the countries of origin reported, the majority were produced in the United States, the standardization of patients was done mainly by histological confirmation of the disease, the general evaluation of the patients, among the groups analyzed by the articles, showed a decrease in prostatespecific antigen (PSA) in responder groups and an increase in cytotoxic and helper T cells after the administration of immunotherapy. The experimental results found demonstrate diversity of cytokine production at 24 hours and 48 hours, with a nonsignificant production of IFN-y, lower cell migration in the PC3 + DC + lymphocytes group and greater cell viability in the PC3 + DC + lymphocytes group. The results suggest that treatment of prostate cancer with immune cells may decrease the invasion of cancer cells, but do not tend to induce cell death. Tipo: Dissertação Thu, 22 May 2025 00:00:00 GMT http://bdtd.uftm.edu.br/handle/123456789/2185 2025-05-22T00:00:00Z http://bdtd.uftm.edu.br/handle/123456789/2184 Título: Biovidros ativos multifuncionais dopados com prata e európio para aplicações biomédicas: caracterização, atividade antibacteriana, citocompatibilidade e potencial regenerativo Abstract: Nanostructured bioactive glasses have emerged as promising biomaterials for bone repair, particularly when functionalized with ions capable of providing antimicrobial properties. This study aimed to evaluate the biological performance of bioactive glasses doped with silver and europium through physicochemical characterization, in vitro assays, and in vivo evaluation in an experimental model. Structural characterization confirmed the formation of a typical SiO₂– Na₂O–CaO–P₂O₅ glass network, with structural modifications associated with silver incorporation. In vitro results demonstrated that silver-containing formulations exhibited concentration-dependent antibacterial and antibiofilm activity against Staphylococcus aureus, Escherichia coli, and Streptococcus mutans, while maintaining high cytocompatibility in Vero cells. Europium incorporation did not significantly influence the evaluated biological parameters. Based on these findings, formulations containing 0.5 wt% and 1.25 wt% silver were selected for in vivo evaluation in a rat calvarial defect model. The results showed that silver concentration directly modulated tissue response, with 0.5 wt% promoting a more pronounced initial inflammatory response, whereas 1.25 wt% was associated with increased collagen deposition and extracellular matrix maturation. In conclusion, silver doping confers multifunctional properties to bioactive glasses, highlighting their potential for bone tissue engineering applications. The dopant concentration plays a critical role in balancing antimicrobial efficacy and biological response. Tipo: Tese Tue, 01 Sep 2026 00:00:00 GMT http://bdtd.uftm.edu.br/handle/123456789/2184 2026-09-01T00:00:00Z http://bdtd.uftm.edu.br/handle/123456789/2183 Título: Síntese e caracterização de nanocristais de perovskita de CsPbI 3 dopados com cobalto Abstract: Perovskites can be formed by different combinations of chemical elements, resulting in a wide variety of structures. This structural diversity allows the production of compounds with distinct physical properties, such as ferroelectricity and pyroelectricity. Thus, the present work aims to synthesize and characterize cobalt-doped CsPbI₃ nanocrystals using the melt method. Doping with divalent metal ions has been considered an effective approach to improve external quantum efficiency due to its effect on reducing non-radiative recombination, lowering charge injection barriers, and enhancing charge carrier transport properties. Moreover, the microstructure and optical properties of the perovskite nanocrystals were characterized by Transmission Electron Microscopy, X-ray Diffraction, UV–Vis–NIR Optical Absorption Spectroscopy, and Photoluminescence. Currently, the literature reports studies on perovskites aimed at optical and electronic applications, with the vast majority focused on ABX₃ perovskites, where X generally belongs to the halogen group or corresponds to the O anion (oxygen), forming ABO₃ compounds. Therefore, in this work, a dopant strategy was developed to elucidate the internal mechanism of Co²⁺ doping, to determine its impact on the structure and properties of CsPbI₃ perovskite quantum dots, and to analyze their performance for optoelectronic applications. Finally, the authors acknowledge the Coordination for the Improvement of Higher Education Personnel (CAPES) for the financial support provided for this research, which was essential for the development of the experimental activities and for obtaining the results presented. Tipo: Dissertação Tue, 10 Feb 2026 00:00:00 GMT http://bdtd.uftm.edu.br/handle/123456789/2183 2026-02-10T00:00:00Z http://bdtd.uftm.edu.br/handle/123456789/2182 Título: Explorando o infinito: uma interpretação sobre o universo filosófico de Giordano Bruno Abstract: This dissertation investigates the cosmological and ontological vision of Giordano Bruno (1548–1600) through the direct analysis of two of his works, De l'infinito, universo e mondi (1584a) and De la causa, principio et uno (1584b), both published in London in 1584. The central objective is to understand how Bruno articulates his description of the universe — infinite, without a fixed center, and inhabited by countless worlds — with his philosophical conception of the nature of God. The methodology adopted is qualitative, bibliographical and historical, grounded in the principles of Marc Bloch as set out in The Historian's Craft (1944), with emphasis on the direct analysis of primary sources in Italian and on the historical contextualization of Brunian thought, without anachronistic projections onto the past. Throughout the chapters, the research reconstructs the biographical, intellectual, and institutional context of Bruno in sixteenth-century Europe; systematically describes the structure and argumentation of the ten dialogues of the analyzed works; and develops a philosophical analysis of Bruno's model of the universe in his two books, organized into three parts: the Aristotelian-Ptolemaic model that Bruno rejects; the model he proposes, based on direct quotations from the texts; and a synthesis that articulates the elements of the system. The results show that the infinitude of the universe is, for Bruno, a necessary consequence of the infinite nature of God, and that each cosmological proposition finds its foundation in a corresponding ontological proposition. The dissertation contributes to expanding Brazilian academic production on Bruno and to the field of the history of science in the context of science and mathematics education. Tipo: Dissertação Mon, 20 Jul 2026 00:00:00 GMT http://bdtd.uftm.edu.br/handle/123456789/2182 2026-07-20T00:00:00Z