Marcadores der estresse oxidativo associam-se à força muscular de membros inferiores e à qualidade de vida global em mulheres na pós-menopausa

Abstract

The objective of this study was to analyze whether there is an association between blood oxidative stress markers with variables of muscular, mental / cognitive health and quality of life in sedentary and physically active postmenopausal women. Were selected 74 postmenopausal women (60.82 ± 8.23 years), who had clinical characteristics, anthropometric, nutritional and life habits data collected. The level of physical activity was measured using the IPAQ-long form questionnaire. The blood markers used were the enzymatic activity of CuZn superoxide dismutase (CuZn-SOD) and catalase (CAT) and the concentration of malondialdehyde (MDA). Muscle strength of the lower limbs was measured using a device with a dynamometer attached, physical performance was assessed by the six-minute walk test, the Montréal Cognitive Assessment – MoCA was utilized to measure cognitive performance, the applied depression scale was the Geriatric Depression Scale (GDS-15) and for global quality of life score, the World Health Organization Quality of Life - OLD version questionnaire was utilized. Linear regression models were made in order to verify associations between oxidative stress markers with lower limb muscle strength, physical performance, cognitive performance, depression scale and global quality of life score. Being the models: model 1: no adjustments; model 2: adjusted for age, body mass index, number of drugs prescribed, intake of antioxidant micronutrients; Model 3: adjusted for age, body mass index, number of drugs prescribed, intake of antioxidant micronutrients and level of physical activity. CuZn-SOD activity was significantly associated with lower limb muscle strength in model 1 (β=.268; p =.023), in model 2 (β=.325; p=.005) and in model 3 (β=.303; p=.002). Similarly, the concentration of MDA was significantly and inversely associated with the global quality of life in model 2 (β= -.245; p=.021) in model 3 (β= -.273; p= .004). There was no significant association between CAT and lower limb strength in any of the three models used (β= .090; p= .432; β= .106; p=.358; β=.117; p=.333, respectively), nor between MDA concentration and lower limb strength in the three models used (β= -.039; p=.742; β= -.040; p=.737; β= -.068; p=.504, respectively). Furthermore, there was also no significant association between CuZn-SOD and global quality of life (β= - .088; p=.458; β= -.090; p=.439; β = -.121; p=.334, respectively), nor between CAT and global quality of life (β=.041; p=.729; β=.001; p=.994; β=.001; p=.987, respectively) in the three models used. Finally, there was no significant association between any of the blood markers (CuZn-SOD, CAT or MDA) with physical performance, cognitive performance and depression scale. The conclusion is that CuZn-SOD enzyme activity is associated with lower limb muscle strength in postmenopausal women. Similarly, the concentration of MDA has an inverse association with global quality of life in the same group. Both associations occur regardless of age, body mass index, intake of antioxidant micronutrients, number of prescription drugs and level of physical activity.