Características patológicas de próstatas de indivíduos necropsiados infectados com o vírus da imunodeficiência humana

Abstract

There is little information in the literature regarding the incidence of prostatic changes among HIV-positive men. From this perspective and assuming that several diseases happen more frequently in these individuals, we identified the types of conditions that affect the prostate, its incidence and possible relationship with demographic data. This is a retrospective, descriptive and quantitative study, performed on necropsied individuals at the Hospital de Clínicas of the Federal University of Triângulo Mineiro (UFTM), from 1995 to 2016 (approved by the UFTM Research Ethics Committee for Human Studies). This study included male patients, with or without HIV infection, with a minimum age of 18 years, with autopsy reports completely filled and prostates in analysis condition. The data obtained were analyzed using descriptive statistics. Ninety-four patients were included in this study, 43 HIV+ patients and 51 HIVpatients. Histopathological examination of the prostates was performed by a blinded pathologist. The main findings were prostate cancer, benign prostatic hyperplasia (BPH), inflammatory infiltrate and atrophy. In the HIV+ group, the average age was 39 (23-67) years while in the HIV- group it was 56 (25-80) years, a highly significant difference (p <0.0001). Five (11.63%) patients in the HIV+ group and 14 (27.45%) patients from the HIV- group were diagnosed with prostate cancer (Fisher's Exact Test; p> 0.05). BPH was observed in 11 (25.58%) HIV+ patients and in 18 (35.29%) HIV- patients (p> 0.05). Inflammatory infiltrate was observed in the prostates of 19 (44.19%) HIV+ patients and 25 (49.02%) HIV- patients (p> 0.05). Prostatic atrophy was observed in 14 (32.56%) patients in the HIV+ group and in 8 (15.69%) in the HIV- group (p> 0.05). The average age of HIV+ patients with BPH and HIV- with BPH was, respectively, 36.18 ± 2.97 and 52.11 ± 3.58 years, this difference being highly significant (p <0.01). The most frequent histopathological findings in the HIV+ group were the presence of inflammatory infiltrate and prostatic atrophy. There was no association between prostate cancer, BPH, presence of inflammatory infiltrate and atrophy with HIV infection. HIV+ patients developed BPH earlier than HIV-.