Biblioteca Digital de Teses e Dissertações PÓS-GRADUAÇÃO SCTRICTO SENSU Programa de Pós-Graduação Multicêntrico em Química de Minas Gerais
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dc.creatorCINTRA, Alessandra Cristina-
dc.creator.ID07753814621pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/5211963605643463pt_BR
dc.contributor.advisor1OLIVEIRA JUNIOR, Robson Tadeu Soares de-
dc.contributor.advisor1ID18129008807pt_BR
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/7783176519114288pt_BR
dc.date.accessioned2022-07-29T16:28:31Z-
dc.date.available2016-10-10-
dc.date.available2022-07-29T16:28:31Z-
dc.date.issued2016-10-10-
dc.identifier.citationCINTRA, Alessandra Cristina. Determinação eletroanalítica de Losartana®, Captopril® e Alisquireno® em fluidos biológicos e em formulações comerciais. 2016. 116f . Dissertação (Mestrado em Química) - Programa de Pós-Graduação Multicêntrico em Química de Minas Gerais, Universidade Federal do Triângulo Mineiro, Uberaba, 2016 .pt_BR
dc.identifier.urihttp://bdtd.uftm.edu.br/handle/123456789/1355-
dc.description.resumoPressão arterial (PA) alterada, é um importante fator de risco para complicações cardiovasculares e renais. O sistema renina-angiotensina-aldosterona (SRAA) tem sido o alvo no centro da fase para todas as complicações cardiovasculares e cardio-renais. Neste sentido, Losartana®, Captopril® e Alisquireno® são medicamentos da classe dos antagonistas dos receptores da angiotensina (ARAs). Deste modo, a presente dissertação visa apresentar métodos de análises fundados em técnicas eletroquímicas por voltametria de onda quadrada (SWV), no intuito de facilitar e viabilizar financeiramente as análises dos fármacos em questão. Os sinais eletroquímicos foram obtidos, através da oxidação eletroquímica dos fármacos, em eletrodo de diamante dopado com boro (DDB). As análises foram feitas em meio eletrolítico de tampão de Britton-Robinson (BR) em diferentes pH’s, onde fixou-se os melhores parâmetros de análise (frequência, amplitude e incremento de varredura). Uma vez otimizados os parâmetros de onda quadrada, foi definida a região linear entre corrente de pico (Ip) vs. concentração. A oxidação dos fármacos revelam picos de oxidação bem definidos e irreversíveis. Para o Alisquireno®, a curva analítica é obtida no intervalo de concentração de 1,81 x 10-5 a 1,63 x 10-4 mol/L (r = 0,997), com limites de detecção e quantificação de 2,5 x 10-8 e 8,4 x 10-8 mol/L, respectivamente. Os valores de recuperação alcançam de 98,2% a 100,2%. Para a Losartana®, a curva analítica é obtida no intervalo de concentração de 9,38 x 10-6 a 8,75 x 10-5 mol/L (r = 0,997), com limites de detecção e quantificação de 2,64 x 10-8 e 8,82 x 10-8 mol/L, respectivamente. Os valores de recuperação alcançam de 96,2% a 113,5%. E finalmente, para o Captopril®, a curva analítica é obtida no intervalo de concentração de 2,70 x 10-5 a 2,30 x 10-4 mol/L (r = 0,995), com limites de detecção e quantificação de 6,67 x 10-8 e 2,22 x 10-7 mol/L, respectivamente. Os valores de recuperação alcançam de 99,7% a 101,0%. Os resultados de recuperação obtidos indicam que não há efeitos de interferência da matriz dos fármacos sobre a determinação analítica dos mesmos. Na análise de Alisquireno® e Captopril® em plasma humano os interferentes comuns do soro não alteraram insignificantemente as análises, rendendo boas médias de recuperação de 95,5% a 97,8%, para Alisquireno® e de 100,6%, para Captopril®. Também pode-se afirmar que o eletrodo de DDB exibiu uma resposta estável, sendo este considerado seletivo e sensível para os fármacos estudados.pt_BR
dc.description.abstractBlood pressure (BP) change is an important risk factor for cardiovascular and renal complications. The renin-angiotensin-aldosterone system (RAAS) has been the target in the center of phase for all the cardiovascular and cardio-renal complications. In this sense, Losartan®, Captopril® and Aliskiren® are drugs in the class of angiotensin receptor (ARBs). Thus, this thesis aims to present methods of analysis grounded in electrochemical techniques by square wave voltammetry (SWV) in order to facilitate and financially viable analysis of the drugs in question. The electrochemical signals were obtained by electrochemical oxidation of drugs in diamond electrode doped with boron (BDD). Analyses were made of electrolytic means of Britton-Robinson buffer (BR) in different pH's where we fixed the best analysis parameters (frequency, amplitude and scan increment). Since the square wave optimized parameters, the linear region was defined between peak current (Ip) vs. concentration. Oxidation of drugs show well defined and irreversible oxidation peaks. For Aliskiren®, the calibration curve is obtained in the concentration range of 1.81 x 10-5 to 1.63 x 10-4 mol/L (r = 0.997), with limits of detection and quantification of 2.5 x 10-8 and 8.4 x 10-8 mol/L, respectively. The recovery values reaching 98.2% to 100.2%. For Losartan®, the calibration curve is obtained in the concentration range of 9.38 x 10-6 to 8.75 x 10-5 mol/L (r = 0.997), with limits of detection and quantification of 2.64 x 10-8 and 8.82 x 10-8 mol/L, respectively. The recovery values reaching 96.2 % to 113.5 %. And finally for Captopril®, the calibration curve is obtained in the concentration range of 2.70 x 10-5 to 2.30 x 10-4 mol/L ( r = 0.995 ) , with limits of detection and quantification of 6.67 x 10-8 and 2.22 x 10-7 mol/L, respectively. The recovery values reaching 99.7 % to 101.0 %. These results indicate that there is no interference effects of the array of drugs on the analytical determination of the same. In Aliskiren® analysis and Captopril® interferents in human plasma serum is common insignificantly altered the analysis, yielding good average recovery of 95.5 % to 97.8 % for Aliskiren® and 100.6 % for Captopril®. It can also say that the BDD electrode showed a stable response, which is considered selective and sensitive to the drugs studied.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal do Triângulo Mineiropt_BR
dc.publisher.departmentInstituto de Ciências Exatas, Naturais e Educação - ICENEpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.initialsUFTMpt_BR
dc.publisher.programPrograma de Pós-Graduação Multicêntrico em Química de Minas Geraispt_BR
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Available at: http://dx.doi.org/10.1016/j.jhazmat.2011.10.087. Ziyatdinova, G.K., Budnikov, G.K. & Pogorel’tsev, V.I., 2006. Determination of captopril in pharmaceutical forms by stripping voltammetry. Journal of Analytical Chemistry, 61(8), pp.798–800. Endereços Eletrônicos: http://www.guiadafarmacia.com.br/edicao-254-especial-farmaceutico/7388-patentes-de-medicamentos http://agenciabrasil.ebc.com.br/geral/noticia/2015-12/anvisa-interdita-lote-de-medicamento-indicado-para-hipertensao); http://exame.abril.com.br/brasil/noticias/anvisa-interdita-lote-de-medicamento-para-hipertensao).pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectEletroquímica.pt_BR
dc.subjectLosartana®.pt_BR
dc.subjectCaptopril®.pt_BR
dc.subjectAlisquireno®.pt_BR
dc.subjectElectrochemistry.pt_BR
dc.subjectLosartan®.pt_BR
dc.subjectCaptopril®.pt_BR
dc.subjectAliskiren®.pt_BR
dc.subjectSWV.pt_BR
dc.subjectDDB.pt_BR
dc.subject.cnpqCNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA ANALITICA::ELETROANALITICApt_BR
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDE::MEDICINA-
dc.titleDeterminação eletroanalítica de Losartana®, Captopril® e Alisquireno® em fluidos biológicos e em formulações comerciaispt_BR
dc.typeDissertaçãopt_BR
Aparece nas coleções:Programa de Pós-Graduação Multicêntrico em Química de Minas Gerais

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