Associação entre atividade física e marcadores inflamatórios e anti-inflamatórios em pessoas com sintomas depressivos

Abstract

Introduction: Depression is highly prevalent in today's society, affecting 17% of the population. It is a disabling condition that causes countless losses in various sectors of society, including health and the economy. Studies have observed a direct relationship between the prevalence of depression and low levels of physical activity. Depressed people tend to reduce their level of physical activity, and physically inactive or sedentary individuals are more likely to experience episodes of depression. On the other hand, the literature suggests that physical exercise can be an effective option for treating and reducing depression in the general population. Furthermore, increasing the level of physical activity may be associated with a reduction in the baseline inflammation state and, consequently, a reduction in depression. Therefore, this dissertation is structured into two articles: a systematic scoping review and a cross-sectional study. Objective: Thus, the objectives are: 1) Carry out a scoping review to evaluate the effect of the level of physical activity in the adult population on inflammatory and anti-inflammatory markers in depressed people and 2) Evaluate the association between the level of physical activity and blood level of C-reactive protein (CRP) in adults with depressive symptoms. Methods: In study 1, searches were carried out in the PubMed/Medline, Web of Science and EMBASE databases, using a detailed search strategy composed of the themes: Physical activity, inflammatory and anti-inflammatory markers and depression, were found and presented nine studies. In study 2, an analysis of the NHANES population database was carried out, analyzing the level of total physical activity and its domains, with the blood level of CRP, with an association being observed both in the crude analysis and in the adjusted analysis, of the level of leisure-time physical activity, with lower CRP concentration in people with depressive symptoms. Conclusion: In article 1, there is a strong correlation between active depressives being less inflamed and sedentary depressives being more inflamed. In Article 2, leisure-time physical activity is the one that most lowers the inflammatory marker PCR in depressive patients.