Polimorfismos do gene VEGF em mulheres com síndromes hipertensivas na gestação.

Abstract

Hypertensive syndromes during pregnancy are considered as a public health problem, being the main cause of maternal and fetal morbimortality. Vascular endothelial growth factor is one of the responsible factors for the regulation of the placental implantation through its effects in the vascular remodeling and in the survival and invasion of the trophoblast. Polimorphisms in gene VEGF can be useful as indicators of susceptibility for the hypertensive syndromes during pregnancy. This study aimed at identifying polimorphisms of gene VEGF +936C/T and -2578C/A. It is a cross-sectional, quantitative study; constituted by 120 women distributed in four groups: Gestational hypertension, superimposed preeclampsia, preeclampsia and/or eclampsia and control group. Characterization of the sample was shown in a prestructured interview and complemented by data from the medical records. For the identification of the polimorphisms it was done DNA extraction, amplification of sequences by Polymerase chain reaction (PCR) with specific primers and analysis by restriction fragment length polymorphism (RFLP). Statistics analysis of the results was done in a descriptive and inferential way. In this casuistry it was not observed association of polymorphism of gene VEGF +936C/T with hypertensive syndromes of pregnancy, although there is a higher frequency of the T-allele in the group of patients with preeclampsia. However, for polymorphism VEGF -2578C/A it is observed a significant difference between control and preeclampsia groups, being Aallele more frequent in the control one (67%). Additional research is necessary, showing more samples and analysis of other polimorphisms.