Associação entre mediadores inflamatórios, dislipidêmicos, índice de massa corporal e nível de atividade física em crianças

Abstract

The purpose of this study was to investigate association among inflammatory markers, dyslipidemic, body mass index (BMI) and physical activity level in children of 10 years age. It was evaluated 94 children, being n = 19 girls and 17 boys eutrophic, n = 18 girls and 16 boys overweight and n = 13 girls and 11 boys obese. Body mass (kg), height (cm) and skinfolds (mm) were measured to calculate BMI and body fat%, respectively. Blood samples were collected after 12 to 14 hours of fasting for measurement of glucose, triglycerides, HDL-c log and inflammation markers (IM) IL-6, TNF-α and CCL-2. The physical activity level was calculated by steps/day average in 7 consecutive days measured by pedometer. The normality of the data was checked by Shapiro-Wilk test and one-way ANOVA with post-hoc Tukey's for multiple comparisons among groups. Associations among inflammatory markers, BMI and physical activity were tested by Pearson correlation. The confidence interval (CI) was 95% and significance level of α ≤ 5%. IL-6, TNF-α and CCL-2 showed moderate negative correlation with HDL-c log (r = - 0.486, r = -0.470, r = - 0.428, p <0.05, respectively) and moderate positive correlation with triglyceride-log (r = 0.568, r = 0.543, r = 0.530, p <0.05, respectively), IMC-log (r = 0.686, r = 0.662, r = 0.608, p <0.05, respectively) and % fat (r = 0.620, r = 0.593, r = 0.592, p <0.05, respectively). The IM did not correlate with the steps / day number (IL-6, r = 0.084, TNF-α, r = 0.090, CCL-2, r = 0.086, p> 0.05). IL-6, TNF-α, CCL-2 and log-triglycerides were higher (p <0.05) in obese children compared to eutrophic, but not those related to overweight (p> 0.05). HDL-c-log was higher among eutrophic children related to overweight and obese (45.5 mg / dL vs. 40 mg / dL vs. 36 mg / dL, p <0.05, respectively). BMI classification seems not to interfere the physical activity level, but overweight and obesity trigger inflammation responses in children of 10 years age and signals the development of cardiovascular diseases such as diabetes, atherosclerosis, hypertension and acute myocardial infarction.