Alterações da matriz cartilaginosa da junção osteocondral de fetos autopsiados.

Abstract

Introduction: The descriptions of the lesions of the JOC are frequent in literature. But the mechanism, the etiológicos factors and which the paper of the production of cartilaginosa matrix in genese of these injuries not yet was clarified. Objective: To identify the possible quantitative alterations of the cartilaginosa matrix located in the osteocondral junction of autopsied embryos and to relate them with fetais illnesses. Methods: 254 blades of osteocondrais junctions of perinatais autopsies had been used. For the morfométrica analysis we use the method Tricômico de Blue Masson. Results: The amount of cartilaginosa matrix was bigger in lesions AMC and MCO (p<005). We do not find difference statistics enters the amount of cartilaginosa matrix enters the lesions of the diagnosised JOC in the three groups of perinatais deaths. In the nativivos with the lesions bizarra in the JOC had a reduction of the amount of cartilaginosa matrix (p<0,05). You autopsy them perinatais with lesions in the JOC present greater age. With lesion with standard bizarro presents minor gestacional age to the birth (p<0,05). It did not have relation enters the death causes and the amount of cartilaginosa matrix in the osteocondral junction you autopsy Them perinatais that had presented restriction of the intrauterine growth had presented minor amount of cartilaginosa matrix in the osteocondral junction. (p<0,05) it did not have relation enters the amount of cartilaginosa matrix in the osteocondral junction and the illnesses of base. In the congenital malformations, the congenital cardiopathies had significantly presented bigger amount of cartilaginosa matrix in the osteocondral junction (p<0,05). Conclusion: The injuries of the osteocondral junction in you autopsy perinatais are associates with alteration of the amount of deposited cartilaginosa matrix enters the cells of the cartilage. As the production of the cartilaginosa matrix the study of the production depends on the association of gênicos stimulatons with ambient factors and degradation of the matrix must be the key for the agreement of the involved mechanisms in these lesions.