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| Campo DC | Valor | Idioma |
|---|---|---|
| dc.creator | COSTA, Tamires Marielem de Carvalho | - |
| dc.creator.ID | 08282663603 | por |
| dc.creator.Lattes | http://lattes.cnpq.br/2430887005991394 | por |
| dc.contributor.advisor1 | OLIVEIRA, Carlo José Freire de | - |
| dc.contributor.advisor1ID | 08736295744 | por |
| dc.contributor.advisor1Lattes | http://lattes.cnpq.br/7006593564297649 | por |
| dc.date.accessioned | 2016-08-01T14:51:24Z | - |
| dc.date.issued | 2014-09-12 | - |
| dc.identifier.citation | COSTA, Tamires Marielem de Carvalho. Efeitos imunossupressores da saliva de Amblyomma cajennense em células dendríticas derivadas de medula óssea murina. 2014. 47f. Dissertação (Mestrado em Ciências Fisiológicas) - Curso de Pós-Graduação em Ciências Fisiológicas, Universidade Federal do Triângulo Mineiro, Uberaba, 2014. | por |
| dc.identifier.uri | http://bdtd.uftm.edu.br/handle/tede/335 | - |
| dc.description.resumo | As células dendríticas (CDs) são células apresentadoras de antígenos profissionais com funções essenciais na ativação da imunidade do hospedeiro. Carrapatos são artrópodes hematófagos que secretam através da saliva, compostos bioativos com propriedades anti-hemostáticas e imunomoduladoras. Sabe-se que algumas espécies de carrapatos modulam a biologia de CDs com diferentes intensidades. No entanto, estudos com Amblyomma cajennense, ainda não foram desenvolvidos, embora esta espécie seja considerada uma das mais qualificadas para imunomodulação justamente por ser capaz de infestar diferentes hospedeiros. Neste trabalho, demonstrou-se que a adição de saliva de A. cajennense em células da medula óssea, inibe a diferenciação de CDs. Esta inibição não foi acompanhada por inibição ou indução de moléculas co- ou estimuladoras, tais como MHC-II, CD40, CD80 e CD86. CDs imaturas ou maduras pré-expostas à saliva mostraram redução da migração estimulada pelas quimiocinas RANTES e MIP-3β, respectivamente. Esta inibição foi mediada pela saliva, que reduziu significativamente a expressão dos receptores de quimiocina CCR5 ou CCR7. A saliva deste carrapato também inibiu, de forma concentração dependente, a produção das citocinas IL-12p40, IL-6 e TNF-α, enquanto potencializou a produção de IL-10 por CDs estimuladas pelo LPS – lipopolissacarídeo - ligante do receptor Toll-like 4 (TLR4). Além disso, a saliva foi capaz de inibir a expressão de CD40 e CD86 em CDs maduras, enquanto que, por si só, potencializou a expressão de PD-L1. A prostaglandina E2 foi detectada (~ 80 nM) como um dos constituintes da saliva e nós acreditamos que parte dos resultados obtidos neste trabalho são devido à presença desta molécula. Desta forma, estes resultados ajudam a compreender a interação carrapato-hospedeiro e exemplificar que os carrapatos da espécie A. cajennense parecem possuir mecanismos específicos para a modulação de células do sistema imunológico do hospedeiro, incluindo as CDs. | por |
| dc.description.abstract | Dendritic cells (DCs) are professional antigen-presenting cells with essential roles in the activation of host immunity. Ticks are blood-sucking arthropods that secrete via saliva, bioactive compounds with immunomodulatory properties. It is known that some tick species modulate the biology of DCs with different intensities; however, studies with Amblyomma cajennense, the cayenne tick, have not yet been developed although this species is considered one of the most qualified for immunomodulation. In this work we demonstrated that the addition of A. cajennense tick saliva to bone marrow cells inhibits the differentiation to DCs. This inhibition was not accompanied by inhibition or induction of co- and stimulatory molecules MHC-II, CD40, CD80 and CD86. Immature or mature DCs pre-exposed to saliva showed reduced migration towards RANTES and MIP-3β chemokines, respectively. This inhibition was mediated by saliva which significantly reduced the expression of CCR5 or CCR7 chemokine receptors. Tick saliva also inhibited, in a concentration-dependent manner, IL-12p40, IL-6 and TNF-α while potentiating IL-10 cytokine production by DCs stimulated by Toll-like receptor-4 ligand. Additionally, the saliva was able to inhibit the expression of CD40 and CD86 in mature DCs while, per se, potentiating the expression of PD-L1. Prostaglandin-E2 was detected (~ 80 nM) as one of the constituents of saliva and we believe that some of the results obtained are due to their presence. Thus, these results help to understand the tick-host interaction and exemplify that ticks of the species A. cajennense seems to have particular mechanisms for modulation of host immune cells, including DCs. | eng |
| dc.description.sponsorship | Fundação de Amparo a Pesquisa do Estado de Minas Gerais - FAPEMIG | por |
| dc.description.sponsorship | Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq | por |
| dc.description.sponsorship | Universidade Federal do Triângulo Mineiro - UFTM | por |
| dc.format | application/pdf | * |
| dc.thumbnail.url | http://bdtd.uftm.edu.br/retrieve/1663/Dissert%20Tamires%20M%20C%20Costa.pdf.jpg | * |
| dc.language | por | por |
| dc.publisher | Universidade Federal do Triângulo Mineiro | por |
| dc.publisher.department | Instituto de Ciências da Saúde - ICS::Curso de Medicina | por |
| dc.publisher.country | Brasil | por |
| dc.publisher.initials | UFTM | por |
| dc.publisher.program | Curso de Pós-Graduação em Ciências Fisiológicas - Parasitologia, Imunologia e Microbiologia | por |
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Coinoculation of Borrelia spp. with tick salivary gland lysate enhances spirochete load in mice and is tick species-specific. J Parasitol, v. 88, n. 6, p. 1276-1278, Dec 2002. | por |
| dc.rights | Acesso Aberto | por |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
| dc.subject | Carrapatos | por |
| dc.subject | Amblyomma cajennense | por |
| dc.subject | Saliva | por |
| dc.subject | Células dendríticas | por |
| dc.subject | Ticks | eng |
| dc.subject | Amblyomma cajennense | eng |
| dc.subject | Saliva | eng |
| dc.subject | Dendritic cells | eng |
| dc.subject.cnpq | Ciências Biológicas | por |
| dc.title | Efeitos imunossupressores da saliva de Amblyomma cajennense em células dendríticas derivadas de medula óssea murina | por |
| dc.type | Dissertação | por |
| Aparece nas coleções: | Programa de Pós-Graduação em Ciências Fisiológicas | |
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