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| Campo DC | Valor | Idioma |
|---|---|---|
| dc.creator | VIEIRA, Jéssica Ferreira | - |
| dc.creator.ID | 08471387638 | por |
| dc.creator.Lattes | http://lattes.cnpq.br/4212471993716956 | por |
| dc.contributor.advisor1 | MICHELIN, Márcia Antoniazi | - |
| dc.contributor.advisor1ID | 11828808865 | por |
| dc.contributor.advisor1Lattes | http://lattes.cnpq.br/2599409028588669 | por |
| dc.contributor.advisor-co1 | MURTA, Eddie Fernando Cândido | - |
| dc.contributor.advisor-co1ID | 47668032649 | por |
| dc.contributor.advisor-co1Lattes | http://lattes.cnpq.br/5724192420139830 | por |
| dc.date.accessioned | 2019-08-26T14:34:22Z | - |
| dc.date.issued | 2017-06-19 | - |
| dc.identifier.citation | VIEIRA, Jéssica Ferreira. Análise da síntese de IL-12 em linfócitos T CD4+ e correlação com fatores de transcrição em pacientes com câncer avançado. 2017. 65f . Dissertação (Mestrado em Ciências da Saúde) - Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Triângulo Mineiro, Uberaba, 2017 . | por |
| dc.identifier.uri | http://bdtd.uftm.edu.br/handle/tede/831 | - |
| dc.description.resumo | No contexto tumoral, o sistema imunológico desempenha papeis que podem prevenir o desenvolvimento ou a progressão tumoral. Assim, a produção de citocinas, principalmente por linfócitos T CD4+, representa um fenômeno crucial na resposta imune, uma vez que variações nesta regulação podem resultar em uma resposta inadequada. Anteriormente, esse grupo de pesquisa demonstrou que linfócitos T CD4+ de pacientes com estádios avançados de câncer expressavam interleucina-12, o mesmo se aplicando a camundongos induzidos a câncer de mama com DMBA (7, 12 – Dimetilbenzantraceno). Então, o objetivo do presente estudo foi avaliar a síntese de IL-12 em linfócitos T CD4+ do sangue periférico de pacientes com câncer, correlacionando com a expressão dos fatores de transcrição T-bet, GATA-3, RORγt e FoxP3, utilizando citometria de fluxo e abordagens moleculares. As células T CD3+CD4+IL-12+ foram isoladas a partir do sangue periférico obtido de pacientes com câncer, utilizando técnica de citometria de fluxo com princípio de cell sorting (triagem de células) e submetidas a análise do perfil transcricional. Os resultados demonstram uma porcentagem significativamente maior de linfócitos T CD3+CD4+IL-12+ no sangue periférico de pacientes com câncer (p<0,0001). E estas expressam o fator de transcrição RORγt, podendo ainda algumas coexpressarem o fator T-bet. Ainda foi observado que algum fator (s) sérico (s) presente no soro dos pacientes com câncer são capazes ainda de induzir a diferenciação de linfócitos T CD3+CD4+IL-12+, sendo notável o aumento na porcentagem destas células em culturas estimuladas com o soro (p=0,0020). Entretanto novas investigações são necessárias, para compreender esse fenótipo de linfócito. | por |
| dc.description.abstract | In the tumor context, the immune system plays roles that can prevent development or progression of tumor. Thus, the production of cytokines by CD4+ T lymphocytes represents a crucial phenomenon in the immune response, because the variations in this regulation may result in an inadequate response. Previously, our research group demonstrated that CD4+ T lymphocytes from advanced cancer patients expressed interleukin-12 and the same was applied to mice induced breast cancer with DMBA (7,12-Dimethylbenzanthracene). The aim of the present study was to evaluate the synthesis of IL-12 in CD4+ T lymphocytes from the peripheral blood of cancer patients, correlating with the expression of T-bet, GATA-3, RORγt and FoxP3 transcription factors. The CD3+CD4+IL-12+ T cells were isolated from the peripheral blood obtained from cancer patients, using flow cytometry technique with cell sorting principle and submitted to transcriptional profile analysis. The results demonstrate a significantly higher percentage of CD3+CD4+IL-12+ T lymphocytes in the peripheral blood of cancer patients (p <0.0001). In addition, these express the transcription factor RORγt, and some may coexpress the T-bet factor. It has been observed that some serum factor (s) present in the serum of cancer patients are still capable of inducing the differentiation of CD3+CD4+IL-12+ T lymphocytes, being remarkable the increase in the percentage of these cells in stimulated cultures with serum (p = 0.0020). However new investigations are needed to understand this lymphocyte phenotype. | eng |
| dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de Minas Gerais | por |
| dc.description.sponsorship | Universidade Federal do Triângulo Mineiro | por |
| dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico | por |
| dc.description.sponsorship | Fundação de Amparo e Pesquisa de Uberaba | por |
| dc.format | application/pdf | * |
| dc.thumbnail.url | http://bdtd.uftm.edu.br/retrieve/5536/Dissert%20J%c3%a9ssica%20F%20Vieira.pdf.jpg | * |
| dc.language | por | por |
| dc.publisher | Universidade Federal do Triângulo Mineiro | por |
| dc.publisher.department | Instituto de Ciências da Saúde - ICS::Programa de Pós-Graduação em Ciências da Saúde | por |
| dc.publisher.country | Brasil | por |
| dc.publisher.initials | UFTM | por |
| dc.publisher.program | Programa de Pós-Graduação em Ciências da Saúde | por |
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The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses. Immunity, v. 37, n. 4, p. 660-673, 2012. ZHU, J.; PAUL, W. E. CD4 T cells: fates, functions, and faults. Blood, v. 112, n. 5, p. 1557- 1569, 2008. | por |
| dc.rights | Acesso Aberto | por |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
| dc.subject | Linfócitos T auxiliares. | por |
| dc.subject | Interleucina 12. | por |
| dc.subject | RORγt. | por |
| dc.subject | T-bet. | por |
| dc.subject | Resposta antitumoral. | por |
| dc.subject | Peripheral helper T lymphocytes. | eng |
| dc.subject | Interleukin-12. | eng |
| dc.subject | RORγt. | eng |
| dc.subject | T-bet. | eng |
| dc.subject | Antitumor response. | eng |
| dc.subject.cnpq | Imunologia Celular | por |
| dc.title | Análise da síntese de IL-12 em linfócitos T CD4+ e correlação com fatores de transcrição em pacientes com câncer avançado | por |
| dc.type | Dissertação | por |
| Aparece nas coleções: | Programa de Pós-Graduação em Ciências da Saúde | |
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