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| Campo DC | Valor | Idioma |
|---|---|---|
| dc.creator | CALÇADO, Maida Silva | - |
| dc.creator.ID | 25537377691 | por |
| dc.creator.Lattes | http://lattes.cnpq.br/5238673238753688 | por |
| dc.contributor.advisor1 | ETCHEBEHERE, Renata Margarida | - |
| dc.contributor.advisor1ID | 19628308882 | por |
| dc.contributor.advisor1Lattes | http://lattes.cnpq.br/3129721698762388 | por |
| dc.date.accessioned | 2019-11-20T16:31:57Z | - |
| dc.date.issued | 2017-09-05 | - |
| dc.identifier.citation | CALÇADO, Maida Silva. Avaliação histopatológica dos efeitos dos anestésicos locais na cicatrização de feridas cirúrgicas: estudo experimental em ratos. 2017. 70f . Dissertação (Mestrado em Ciências da Saúde) - Programa de Pós-graduação em Ciências da Saúde, Universidade Federal do Triângulo Mineiro, Uberaba, 2017 . | por |
| dc.identifier.uri | http://bdtd.uftm.edu.br/handle/tede/919 | - |
| dc.description.resumo | INTRODUÇÃO O alívio da dor após cirurgia continua sendo um dos maiores desafios médicos. A infiltração da incisão cirúrgica com anestésicos locais é cada vez mais utilizada, particularmente daqueles de longa duração. OBJETIVO Avaliar a interferência da infiltração de anestésicos locais de longa duração na incisão cirúrgica sobre as áreas do infiltrado inflamatório e da cicatriz fibrosa em ratos. MATERIAL E MÉTODO Estudo experimental envolvendo 40 ratos Wistar, 20 machos e 20 fêmeas. Foram realizadas duas incisões lineares com cerca de 2 cm no dorso de cada animal, simétricas em relação à linha média, sendo a esquerda infiltrada com doses de 1,8 mlde Bupivacaína, Levobupivacaína ou Ropivacaínae a da direita sem infiltração. Outro grupo recebeu aplicação de soro fisiológico 0,9 % na incisão à esquerda e nenhuma aplicação à direita. Após sete dias foram colhidas amostras das duas incisões para avaliação morfométrica. RESULTADOS Quando comparados com os controles, a área do infiltrado inflamatório foi maior nos grupos Bupivacaína, Ropivacaína e Levobupivacaína. A Bupivacaína apresentou infiltrado inflamatório maior que a Levobupivacaína e Ropivacaína. A área da cicatriz fibrosa foi maior nos grupos Levobupivacaína e Ropivacaína. Não houve diferença quando comparados os grupos com aplicação de anestésicos e o soro fisiológico. CONCLUSÃO A infiltração local de anestésicos associou-se a maior área de infiltrado inflamatório, principalmente a Bupivacaína, e de fibrose. A Levobupivacaína, apesar de associar-se a menor infiltrado, se associou a maior área de cicatriz fibrosa. Como não houve diferença entre os anestésicos e o soro fisiológico, provavelmente o volume aplicado ou o trauma seja a causa das maiores áreas de infiltrado e cicatriz observadas. | por |
| dc.description.abstract | INTRODUCTION Pain relief after surgery remains one of the greatest medical challenges. The infiltration of the surgical incision with local anesthetics has been increasingly used. OBJECTIVE To evaluate the interference of infiltration of local anesthetics in the incision on the areas of inflammatory infiltrate and fibrous scar in rats. MATERIAL AND METHOD Study involving 40 Wistar rats. Two linear incisions each were made on the dorsal region of each animal. The left incision was infiltrated with doses of 1.8ml of Bupivacaine, Levobupivacaine, Ropivacaine or 0,9% saline solution, and the right incision did not receive any infiltration. After seven days, samples of the incisions were collected for morphometric evaluation. RESULTS When compared with the control groups, the area of inflammatory infiltrate was found larger in the Bupivacaine, Ropivacaine and Levobupivacaine groups. The Bupivacaine group presented larger inflammatory infiltrate than the Levobupivacaine and Ropivacaine. The fibrous scar area was larger in the Levobupivacaine and Ropivacaine groups. There was no difference between the groups that received anesthetic and saline solution. CONCLUSION Local infiltration of anesthetics was associated with largest area of inflammatory infiltrate and fibrosis. Despite being associated with the largest infiltrate, Bupivacaine was associated with the smallest area of fibrous scar. Despite being associated with the smallest infiltrate, Levobupivacaine was associated with the largest area of fibrous scar. As there was no difference between the anesthetics and saline solution groups, the volume applied or the trauma may have been the cause of the larger areas of infiltrate and scar observed. | por |
| dc.format | application/pdf | * |
| dc.thumbnail.url | http://bdtd.uftm.edu.br/retrieve/6193/Dissert%20Maida%20S%20Cal%c3%a7ado.pdf.jpg | * |
| dc.language | por | por |
| dc.publisher | Universidade Federal do Triângulo Mineiro | por |
| dc.publisher.department | Instituto de Ciências da Saúde - ICS::Programa de Pós-Graduação em Ciências da Saúde | por |
| dc.publisher.country | Brasil | por |
| dc.publisher.initials | UFTM | por |
| dc.publisher.program | Programa de Pós-Graduação em Ciências da Saúde | por |
| dc.relation.references | ABRÃO, J., et al. Effect of local anaesthetic infiltration with bupivacaine and ropivacaine on wound healing: a placebo-controlled study. Int Wound J, v.11, n.4, p.379-385, 2014. ALA-KOKKO, T. I. et al. Pharmacokinetics of 0.75% ropivacaine and 0.5% bupivacaine after ilioinguinal–iliohypogastric nerve block in children. Br JAnaesth, v. 89, n. 3, p. 438-441, 2002. ANGOOD, P.B., GINGALEWSKI, C.A., ANDERSEN. D.K. Surgical complications. In: TOWNSEND CM Jr, ed. Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice, 16th ed. Philadelphia, PA: Saunders; 2001, p.198-225. ANSALONI L., et al. The analgesic efficacy of continuous elastomeric pump ropivacaine wound instillation after appendectomy. J ClinAnesth, v. 19, p.256-263, 2007. APFELBAUM, J. L. et al. Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. AnesthAnalg, v. 97, n. 2, p. 534-22 540, 2003. ARMITAGE, J.; LOCKWOOD, S. Skin incisions and wound closure. Surgery v. 29, n.10, p.496-501, 2011. ASCIONEA, F., CASERTA, S., GUIDO, S. The wound healing assay revisited: A transport phenomena approach. Chem. Eng. Sci, v.160, p.200–209, 2017. AYDIN, O. N.; EYIGOR, M.; AYDIN, N. Antimicrobial activity of ropivacaine and other local anaesthetics. Eur J Anaesthesiol, v. 18, n. 10, p. 687-694, 2001. BAMIGBOYE, A. A.; JUSTUS, H. G. Ropivacaine abdominal wound infiltration and peritoneal spraying at cesarean delivery for preemptive analgesia. Int J GynaecolObstet, v. 102, p.160-164, 2008. BANKS, A. Innovations in postoperative pain management: continuous infusion of local anesthetics. AORN journal, v. 85, n. 5, p. 904-918, 2007. BANZ, V. M.; JAKOB, S. M.; INDERBITZIN, D. Improving outcome after major surgery: pathophysiological considerations. AnesthAnalg, v. 112, n. 5, p. 1147-1155, 2011. BARANIDHARAN, G.; BRIGGS, M. Local and regional anaesthetic techniques in wound management. Surgery, v.32, n.9, p.447-461, 2014. BAY-NIELSEN, M. et al. Levobupivacainevs bupivacaine as infiltration anaesthesia in inguinal herniorrhaphy. Br JAnaesth, v. 82, n. 2, p. 280-282, 1999. BEAUSSIER, M.; AISSOU, M. Single-shot wound infiltration for postoperative analgesia. Neurosurgery, ENT, thoracic abdominal and perineal surgery. Ann FrAnesthReanim, v.28, n.3, p.e163-73, 2009. BEAUSSIER, M, et al. Continuous preperitoneal infusion of ropivacaine provides effective analgesia and accelerated recovery after colorectal surgery. A randomized, double-blind, placebocontrolled study. Anesthesiology,v.107, p.461–468, 2007. BENTOV, I.; REED, M. I. Anesthesia, Microcirculation, and Wound Repair in Aging. Anesthesiology, v.120, n.3, p.760-772, 2014. BRENNAN, T. J.; ZAHN, P. K.; POGATZKI-ZAHN, E. M. Mechanisms of incisional pain. Anesthesiology clinics of North America, v. 23, n. 1, p. 1-20, 2005. BRENNAN, T. J.Pathophysiology of postoperative pain.PAIN, v.152, n.3, p.S33-S40, 2011. BROUGHTON, G.; JANIS, J.; ATTINGER, C. Wound healing: an overview. PlastReconstrSurg, v.117, p.1e-S-32e-S, 2006. BROWER, M. C.; JOHNSON, M. E. Adverse effects of local anesthetic infiltration on wound healing. RegAnesthPainMed, v.28, n.3 (May–June), p.233–240, 2003. CANGIANI L. H.; CANGIANI, L. M.; PEREIRA A. M. S. A. Bupivacaína com Excesso Enantiomérico (S75-R25) a 0,5%, Bupivacaína Racêmica a 0,5% e Lidocaína a 2% no Bloqueio do Nervo Facial pela Técnica de O’Brien: Estudo Comparativo. RevBrasAnestesiol, v.57, n.2, p.136-146, 2007. CAPDEVILA, X. et al. Continuous three-in-one block for postoperative pain after lower limb orthopedic surgery: where do the catheters go? AnesthAnalg, v. 94, n. 4, p. 1001-1006, 2002. CASSUTO, J.; SINCLAIR, R.; BONDEROVIC, M. Anti-inflammatory properties of local anesthetics and their present and potential clinical implications. ActaAnaesthesiolScand, v.50, p.265–82, 2006. CHALFIN, D. B. et al. Impact of delayed transfer of critically ill patients from the emergency department to the intensive care unit. CriticalCare Medicine, v. 35, n. 6, p. 1477-1483, 2007. CHAPMAN, J. L. R, LALKHEN, A. G Modelo fisiológico da experiência dolorosa: Postoperative analgesia. Anaesthesia e Intensive Care, v.17, n.3, p.144-50, 2016. CHILDS, D. R.; MURTHY, A. S. Overview of Wound Healing and Management. SurgClin N Am, v.97, n.1, p.189–207, 2017. CHU, C. R., et al. In vitro exposure of 0.5% bupivacaine is cytotoxic to bovine articular chondrocytes. Arthroscopy, v.22, p.693-699, 2006. CLARK, R. A. Basics of cutaneous wound repair. J DermatolSurgOncol, v.19, p.693-706, 1993. CRILE, G. W. The kinetic theory of shock and its prevention through anoci-association (shockless operation). The Lancet, v. 182, n. 4688, p. 7-16, 1913. DADURE, C. et al. Continuous peripheral nerve blocks at home for treatment of recurrent complex regional pain syndrome I in children. J Am SocAnesthesiol, v. 102, n. 2, p. 387-26 391, 2005. DAHL, J. B.; MOINICHE, S.; KEHLET, H. Wound infiltration with local anaesthetics for postoperative pain relief [review]. ActaAnaesthesiolScand, v.38, p.7-14, 1994. DAHL, V., RAEDER, J. C. Non-opioid postoperative analgesia. ActaAnaesthesiolScand, 2000;44:1191-1203, 2000. DAHL, J. B. et al. Post‐operative analgesic effects of paracetamol, NSAIDs, glucocorticoids, gabapentinoids and their combinations: a topical review. ActaAnaesthesiolScand, v. 58, n. 10, p. 1165-1181, 2014. DRUCKER, M., et al. Experimental studies on the effect of lidocaine on wound healing. World J Surg, v.22, n.4, p.394-7, 1998. ENOCH, S., JOHN LEAPER, D. Basic science of wound healing. Surgery (Oxford); v.23, p.37-42, 2005. EPSTEIN, H. F. Cutaneous wound healing. N Engl J Med, v.341, p.738-746, 1999. ERICHSEN, C. J. et al. Wound infiltration with ropivacaine and bupivacaine for pain after inguinal herniotomy. Actaanaesthesiolscand, v. 39, n. 1, p. 67-70, 1995. ERIKSSON, A. S.; SINCLAIR, R. Leukocyte hydrogen peroxide production in a surgical wound in mice. The effects of an amide local aneasthetic. Inflammation, v.20, n.5, p.569-79, 9 1996. EROGLU, E., et al. The effect of lidocaine/prilocaine cream on na experimental wound healing model. Eur J Emerg Med, v.8, n.3, p.199-201, 2001. FAULDS, D. Ropivacaine: an update of its use in re-gionalanaesthesia. Drugs, v. 60, p. 1065-17 1093, 2000. FOWLER, S. J. et al. Epidural analgesia compared with peripheral nerve blockade after major knee surgery: a systematic review and meta-analysis of randomized trials. Br JAnaesth, v. 22 100, n. 2, p. 154-164, 2008. FREDMAN, B., et al. The analgesic efficacy of patient-controlled ropivacaine instillation after cesarean delivery. AnesthAnalg, v.91, p.1436-1440, 2000. GAN, T. J. et al. Consensus guidelines for managing postoperative nausea and vomiting. AnaesthAnalg, v. 118, n. 1, p. 85-113, 2014. GARCIA, J. B. S., et al. Estudo Comparativo entre Levobupivacaína a 0,5% e Bupivacaína Racêmica a 0,5% Associadas ao Sufentanil na Anestesia Peridural para Cesariana. Rev Bras Anestesiol, v.51, n.5, p.377-384, 2001. GILLITZER, R., GOEBELER, M. Chemokines in cutaneous wound healing. J LeukocBiol, v. 69, p.513–21, 2001. GOLDMAN, R. Growth factors and chronic wound healing: past, present, and future. Adv Skin Wound Care, v.17, n.1, p.24–35, 2004. GOLEMBIEWSKI, J.; DASTA, J. Evolving Role of Local Anesthetics in Managing Postsurgical Analgesia. ClinTher, v.37, n.6, p.1354-71, 2015. GOMOLL, A. H. et al. Chondrolysis after continuous intra-articular bupivacaine infusion: an experimental model investigating chondrotoxicity in the rabbit shoulder. Arthroscopy: The Journal of Arthroscopic & Related Surgery, v. 22, n. 8, p. 813-819, 2006. GORDON, S. M., et al. Attenuation of pain in a randomized trial by suppression of peripheral nociceptive activity in the immediate postoperative period. AnesthAnalg,v.95, p.1351-1375, 7 2002. GOTTSCHALK, A.; RAJA, S. N. Severing the Link between Acute and Chronic PainThe Anesthesiologist's Role in Preventive Medicine. J Am SocAnesthesiol, v. 101, n. 5, p. 1063-12 1065, 2004. GREENHALGH, D. G. The role of apoptosis in wound healing. Int J Biochem Cell Biol, v.30, p.1019-1030, 1998. HANCI, V.; et al. Comparision of the effects of Bupivacaine, Lidocaine, and Tramadol infiltration on Wound Healing in rats. RevBrasAnestesiol, v.62, n.6, p.799-810, 2012. HIRATA, M., et al. Lidocaine inhibits tyrosine kinase activity of the epidermal growth factor receptor and suppresses proliferation of corneal epithelial cells. Anesthesiology, v.100, n.5, 25 p.1206-10, 2004. HORLOCKER, T.; KOPP, S. Epidural hematoma after epidural blockade in the United States: it’s not just low molecular heparin following orthopedic surgery anymore. AnesthAnalg, v.116, n.6, p.1195-1197. 2013. KAHOKEHR, A., et al. Intraperitoneal use of local anesthetic in laparoscopic cholecystectomy: systematic review and meta-analysis of randomized controlled trials. J HepatobiliaryPancreatSci, v.17, p.637–656, 2014. KAKAGIA, D.; FOTIADIS, S.; TRIPSIANNIS, G. Levobupivacaine versus ropivacaine infiltration analgesia for mastopexy: a comparative study of 2 long-acting anesthetic drugs in infiltrative anesthesia for mastopexy. Annals of plastic surgery, v. 55, n. 3, p. 258-261, 41 2005. KALSO E. Persistent postsurgery pain: research agenda for mechanisms, prevention, and treatment. Br J Anaesth, v.111, p.9–12, 2013. KEHLET, H.; DAHL, J. B. The value of" multimodal" or" balanced analgesia" in postoperative pain treatment. AnesthAnalg, v. 77, n. 5, p. 1048-1056, 1993. KEHLET, H.; HOLTE, K. Effect of postoperative analgesia on surgical outcome. Br JAnaesth, v. 87, n. 1, p. 62-72, 2001. KEHLET, H.; JENSEN, T. S.; WOOLF, C. J. Persistent postsurgical pain: risk factors and prevention. The Lancet, v. 367, n. 9522, p. 1618-1625, 2006. KEHLET, H.; LIU, S. S. Continuous Local Anesthetic Wound Infusion to Improve Postoperative OutcomeBack to the Periphery?.J Am SocAnesthesiol, v. 107, n. 3, p. 369-371, 11 2007. KIM, WJ-H.; GITTES, G. K.; LONGAKER, M. T. Signal transduction in wound pharmacology. Arch Pharm Res, v.21, n.5, p.487-95, 1998. KINGSNORTH, A. N.; CUMMINGS, C. G.; BENNETT, D. H. Local anaesthesia in elective inguinal hernia repair: A randomised, double‐blind study comparing the efficacy of levobupivacaine with racemic bupivacaine. Eur J Surg, v. 168, n. 7, p. 391-396, 2002. KISSIN, I. The development of new analgesics over the past years: a lack of real breakthrough drugs. AnesthAnalg, v. 110, n. 3, p. 780-789, 2010. KOOIJ, F. O. et al. Does regional analgesia for major surgery improve outcome? Focus on epidural analgesia. AnesthAnalg, v. 119, n. 3, p. 740-744, 2014. KRAFTS, K. P. Tissue repair: the hidden drama. Organogenesis, v.6, p.225-233, 2010. LAHAV, M., et al. Lidocaine inhibits secretion of IL-8 and IL-1beta and stimulates secretion of IL-1 receptor antagonist by epithelial cells. ClinExpImmunol, v.127:226–33, 2002. LAW-KOUNE, J. et al. Scalp infiltration with bupivacaine plus epinephrine or plain ropivacaine reduces postoperative pain after supratentorial craniotomy. Journal of neurosurgical anesthesiology, v. 17, n. 3, p. 139-143, 2005. LECH, M.; ANDERS, H. Macrophages and fibrosis: how resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair. BiochimBiophysActa, v.1832, n.7, p.989-97, 2013. LEHMANN, K. A. Recent developments in patient-controlled analgesia. Journal of pain and Symptom Management, v. 29, n. 5, p. 72-89, 2005. LESLIE, K. et al. Neuraxial block, death and serious cardiovascular morbidity in the POISE trial. Br JAnaesth, v. 111, n. 3, p. 382-390, 2013. LIU, S. S. et al. Effects of perioperative analgesic technique on rate of recovery after colon surgery. J Am SocAnesthesiol, v. 83, n. 4, p. 757-765., 1995. LIU, S. S. et al. Efficacy of continuous wound catheters delivering local anesthetic for postoperative analgesia: a quantitative and qualitative systematic review of randomized controlled trials. Journal of the American College of Surgeons, v. 203, n. 6, p. 914-932, 12 2006. LOIZIDES, S., et al. Wound infiltration with local anaesthetic agents for laparoscopic cholecystectomy. Cochrane Database Syst Rev, v.12, n.3, 2014. LOVICH-SAPOLA, J., SMITH, C. E., BRANDT, C. P. Postoperative pain control. SurgClin North Am, v.95, n.2, p.301-18, 2015. MACINTYRE, P. E. et al. Acute pain management: scientific evidence. Aufl. ANZCA & 24 FPM, Melbourne, 2010. MARKS, J. L.; ATA, B.; TULANDI, T. Systematic review and metaanalysis of 28 intraperitoneal instillation of local anesthetics for reduction of pain after gynecologic 29 laparoscopy. J MinimInvasGyn, v. 19, n. 5, p. 545-553, 2012. MATHIESEN, O. et al. Need for improved treatment of postoperative pain. Danish medical journal, v. 59, n. 4, 2012. MATINSSON, T., et al. Ropivacaine and lidocaine inhibit proliferation of nontransformed cultured adult human fibroblasts, endotelial cells, and keratinocytes. Agents Actions, v. 40, 38 p.78-85, 1993. MCCLAIN, S. A., et al. Mesenchymal cell activation is the rate-limiting step of granulation tissue induction. Am J Pathol, v.149, p.1257-1270, 1996. MEISSNER, W. et al. Improving the management of post-operative acute pain: priorities for change. Curr Med Res Opin, v. 31, n. 11, p. 2131-2143, 2015. MOUNIR, K., et al. Efficiency of bupivacaine wound subfasciale infiltration in reduction of postoperative pain after inguinal hernia surgery. Ann FrAnesthReanim, v.29 p.274–278, 2 2010. MULROY, M. F.; BURGESS, F. W.; EMANUELSSON, B. Ropivacaine 0.25% and 0.5%, but not 0.125%, provide effective wound infiltration analgesia after outpatient hernia repair, but with sustained plasma drug levels. RegAnesth Pain Med, v. 24, n. 2, p. 136-141, 1999. MUSIAL, F.; SPOHN, D.; ROLKE, R. Naturopathic reflex therapies for the treatment of chronic back and neck pain-part 1: neurobiological foundations. ForschendeKomplementärmedizin/Research in Complementary Medicine, v. 20, n. 3, p. 11 219-224, 2013. NAUTA, A., GURTNER, G., LONGAKER, M. Wound healing and regenerative strategies. Oral Dis, v.18, n.17, p.541–549, 2011. ODERDA, G. M. et al. Opioid-related adverse drug events in surgical hospitalizations: impact on costs and length of stay. Annals of Pharmacotherapy, v. 41, n. 3, p. 400-407, 2007. ODERDA, G. M. et al. Effect of opioid-related adverse events on outcomes in selected surgical patients. Journal of pain & palliative care pharmacotherapy, v. 27, n. 1, p. 62-70, 24 2013. PAPAGIANNOPOULOU, P., et al. Preincisional local infiltration of levobupivacainevsropivacaine for pain control after laparoscopic cholecystectomy. Surgical Endoscopy and Other Interventional Techniques, v. 17, n. 12, p. 1961-1964, 2003. PASERO, C. Perineural Local Anesthetic Infusion: When close is almost perfect. AJN The American Journal of Nursing, v. 104, n. 7, p. 89-93, 2004. PAUL, J. E., et al. Femoral Nerve Block Improves Analgesia Outcomes after Total Knee ArthroplastyA Meta-analysis of Randomized Controlled Trials. J Am SocAnesthesiol, v. 38 113, n. 5, p. 1144-1162, 2010. PAUL, J. E., et al. Hamilton Acute Pain Service Safety StudyUsing Root Cause Analysis to Reduce the Incidence of Adverse Events. J Am SocAnesthesiol, v. 120, n. 1, p. 97-109, 2014. PERE, P., et al. Local myotoxicity of bupivacaine in rabbits after continuous supraclavicular brachial plexus block. RegAnesth, v.18, p.304-307, 1993. PERKINS, F. M.; KEHLET, H.. Chronic pain as an outcome of surgery. A review of 1 predictive factors. J Am SocAnesthesiol, v. 93, n. 4, p. 1123-1133, 2000. PETTERSSON, N. et al. High-dose ropivacaine wound infiltration for pain relief after inguinal hernia repair: a clinical and pharmacokinetic evaluation. RegAnesth Pain Med, v. 5 23, n. 2, p. 189-196, 1998 PITKÄNEN, M. T., et al. Serious complications associated with spinal and epidural 9 anaesthesia in Finland from 2000 to 2009. ActaAnaesthesiolScand, v. 57, n. 5, p. 553-564, 10 2013. POLGLASE, A. L., et al. – Continuous wound infusion of local anesthetic for the control of 14 pain after elective abdominal colorectal surgery. Dis Colon Rectum, v.50, p.2158-2167, 15 2007. PÖPPING, D. M. et al. Impact of epidural analgesia on mortality and morbidity after surgery: 19 systematic review and meta-analysis of randomized controlled trials. Annals of surgery, v. 20 259, n. 6, p. 1056-1067, 2014. RAEDER, J. C. Local infiltration analgesia for pain after total knee replacement surgery: a 24 winner or just a strong runner-up? AnesthAnalg, v. 113, n. 4, p. 684-686, 2011. RAJA, S. K.; GARCIA, M. S.; ISSEROFF, R. R. Wound re-epithelialization: modulating 28 keratinocyte migration in wound healing. Front Biosci, v.12, p.2849-2868, 2007. RAINES, S., et al. Ropivacaine for continuous wound infusion for postoperative pain 32 management: a systematic review and meta-analysis of randomized controlled trials. EurSurg 33 Res, v.53, p.43–60, 2014. RATHMELL, J. P. et al. Acute post-surgical pain management: a critical appraisal of current practice. RegAnesth Pain Med, v. 31, n. 4, p. 1-42, 2006. RAWAL, N. Current issues in postoperative pain management. Eur J Anaesthesiol, v.33, p.60–171, 2016. RAWAL, N. Epidural technique for postoperative pain: gold standard no more?.RegAnesth Pain Med, v. 37, n. 3, p. 310-317, 2012. RAWAL, N. Perineural catheter analgesia as a routine method after ambulatory surgery – effective but unrealistic. RegAnesth Pain Med, v.37, p.72-78, 2012. RAWAL, N.; BERGGREN, L. Organization of acute pain services: a low-cost model. Pain, v. 57, n. 1, p. 117-123, 1994. READY, B. L. Acute pain: lessons learned from 25,000 patients. RegAnesth Pain Med, v. 6 24, n. 6, p. 499-505, 1999. REINKE, J. M.; SORG, H. Wound Repair and Regeneration. EurSurg Res, v.49, p.35-43, 10 2012. RENCK, H. Wound infiltration with local anaesthetics. ActaAnaesthesiol Scand,v.38, p.2-6, 1994. RICHMAN, J. M. et al. Does continuous peripheral nerve block provide superior pain control to opioids? A meta-analysis. AnesthAnalg, v. 102, n. 1, p. 248-257, 2006. RIOS, M. A.G, et al. Eficaciaanalgesica de lainfusion continua de anestesico local enlaheridaquirurgicatras histerectomia abdominal. Rev. Esp. Anestesiol. Reanim., v. 56, 23 p.417-424, 2008. ROBSON, M.C.; STEED, D. L.; FRANZ, M. G. Wound healing: biologic features and approaches to maximize healing trajectories. CurrProblSurg, v. 38: 72-140, 2001. ROSSELAND, L. A.; ROMUNDSTAD, L. Multimodal pain management with glucocorticoids: killing two birds with one stone or shooting sparrows with cannons?.ActaAnaesthesiolScand, v. 57, n. 7, p. 819-822, 2013. ROWLINGSON, J. C. How can local anesthetic in the wound not help? AnesthAnalg, v.92, 36 p.3-4, 2001. SAKELLARIS, G., et al.Effects of Ropivacaine Infiltration on Cortisol and Prolactin Responses to Postoperative Pain After Inguinal Hernioraphy in Children. J PediatrSurg, 41 v.39, n.9, p.1400-1403, 2004. SAKURAGI, T.; ISHINO, H.; DAN, K. Bactericidal activity of clinically used local anesthetics on Staphylococcus aureus. RegAnesth Pain Med, v. 21, n. 3, p. 239-242, 1996. SCHERB, M. B., et al. Effect of bupivacaine on cultured tenocytes. Orthopedics, v.32, p.26–49 30, 2009. SCHULZ, C.; GOMEZ PERDIGUERO, E., CHORRO, L., et al. A lineage of myeloid cells independente of Myb and hematopoietic stem cells. Science, v.336, p.86-90, 2012. SCOTT, N. B. Wound infiltration for surgery. Anaesthesia, v. 65, n. s1, p. 67-75, 2010. SEGERDAHL, M. et al. Clinical practice and routines for day surgery in Sweden: results from a nation‐wide survey. ActaAnaesthesiolScand, v. 52, n. 1, p. 117-124, 2008. SPRENG, U. J., et al. High-volume local infiltration analgesia combined with intravenous or local ketolorac þ morphine compared with epidural analgesia after total knee arthroplasty. Br J Anaesth,v.105, p.675–682, 2010. STEINHOFF, M., et al. Modern aspects of cutaneous neurogenic inflammation. Arch Dermatol, v. 139, p.1479-1488, 2003. SVIRCEVIC, V. et al. Meta-analysis of thoracic epidural anesthesia versus general anesthesia for cardiac surgery. JAmSocAnesth, v. 114, n. 2, p. 271-282, 2011. TAKAHASHI, S. Local anesthetic bupivacaine alters function of sarcolasmic reticulum and sarcolemnal vesicles from rabbit masseter muscle. PharmacolToxicol, v.75, p.119–28, 1994. TARNUZZER, R. W.; SCHULTZ, G. S. Biochemical analysis of acute and chronic wound environments. Wound Repair Regen, v.4, p.321-325, 1996. VAURIO, L. E. et al. Postoperative delirium: the importance of pain and pain management. 34 AnesthAnalg, v. 102, n. 4, p. 1267-1273, 2006. 35 VEERING, B. T. Complications and local anaesthetic toxicity in regional anaesthesia. 38 CurrOpinAnaesthesiol, v.16, n.5, p.455-459, 2003. 39 VENTHAM, N. T. et al. Evaluation of novel local anesthetic wound infiltration techniques for 42 postoperative pain following colorectal resection surgery: a meta-analysis. Diseases of the 43 Colon & Rectum, v. 57, n. 2, p. 237-250, 2014. 44 VENTHAM, N. T, et al. Systematic review and metaanalysis of continuous local anaesthetic wound infiltration versus epidural analgesia for postoperative pain following abdominal surgery. Br J Surg, v.100, p.1280–1289, 2013. VIDMAR, J.; CHINGWARU, C.; CHINGWARU, W. Mammalian cell models to advance our understanding of wound healing: a review. J Sur Res, v.210, p.269-280, 2017. VOLK, T. et al. Incidence of spinal haematoma after epidural puncture: analysis from the German network for safety in regional anaesthesia. Eur J Anaesthesiol (EJA), v. 29, n. 4, p. 6 170-176, 2012. WAITE, A., et al. Clinically relevant doses of lidocaine and bupivacaine do not impair cutaneous wound healing in mice. Br J Anaesth, v.104, p.768-773, 2010. WERNER, S.; GROSE, R. Regulation of wound healing by growth factors and cytokines. 14 Physiol Rev, v. 83, p.835-870, 2003. 15 WERNER, M. U. et al. Does an acute pain service improve postoperative 18 outcome?.AnesthAnalg, v. 95, n. 5, p. 1361-1372, 2002. 19 WOOLF, C. Central sensitization: Implications for the diagnosis and treatment of pain. 22 PAIN, v.152, p.S2–S15, 2011. 23 WU, C. L. et al. The effect of pain on health-related quality of life in the immediate 26 postoperative period. AnesthAnalg, v. 97, n. 4, p. 1078-1085, 2003. WU, C. L.; RAJA, S. N. Treatment of acute postoperative pain. The Lancet, v. 377, n. 9784, 30 p. 2215-2225, 2011. 31 YANG, J. et al. Hemodynamic changes due to infiltration of the scalp with epinephrine- containing lidocaine solution a hypotensive episode before craniotomy. J NeurosurgAnesthesiol, v. 19, n. 1, p. 31-37, 2007. XIN, Y.; HONG, Y.; YONG, L. Z. Efficacy of postoperative continuous wound infiltration with local anesthesia after open hepatectomy. Clin J Pain, v.30, p.571-576, 2014. ZINK, W. et al. The long term myotoxic effects of bupivacaine and ropivacaine after continuous peripheral nerve blocks. AnesthAnalg, v. 101, n. 2, p. 548-554, 2005. | por |
| dc.rights | Acesso Aberto | por |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
| dc.subject | Cicatrização. | por |
| dc.subject | Inflamação. | por |
| dc.subject | Bupivacaína. | por |
| dc.subject | Levopubivacaína. | por |
| dc.subject | Ropivacaína. | por |
| dc.subject | Scarring. | eng |
| dc.subject | Inflammation. | eng |
| dc.subject | Bupivacaine. | eng |
| dc.subject | Levobupivacaine. | eng |
| dc.subject | Ropivacaine. | eng |
| dc.subject.cnpq | Medicina | por |
| dc.title | Avaliação histopatológica dos efeitos dos anestésicos locais na cicatrização de feridas cirúrgicas: estudo experimental em ratos | por |
| dc.type | Dissertação | por |
| Aparece nas coleções: | Programa de Pós-Graduação em Ciências da Saúde | |
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