Análise histomorfométrica do osso trabecular de indivíduos com AIDS autopsiados

Abstract

Introduction: people with AIDS can present with age-related and non-age-related illnesses earlier than uninfected persons, including bone diseases. Objective: To analyze the trabecular bone matrix and total collagen density of autopsy from fragments from people with and without aids at the Hospital de Clínicas of the Universidade Federal do Triângulo Mineiro. Methodology: Observational, retrospective study with a quantitative approach with autopsied human beings, performed from 60 bone marrow fragments from autopsied individuals, aged between 26 and 71 years, divided into four groups, adults and elderly with or without AIDS. For histomorphometric analysis, histomorphometric techniques with common light microscopy were used for quantitative analysis of the thickness and microscopy technique with polarized light for evaluation of total collagen in bone trabeculae. Results: The adult and elderly groups with dissipation AIDS decreased in the thickness of the bone trabeculae compared to the groups of adults and elderly without AIDS (p <0.001). In the assessment of collagen in groups of adults and elderly people with AIDS, there was a significant increase in total collagen (p<0.001) compared to groups without AIDS. When comparing adults and elderly people with AIDS, there was a significant increase in total collagen in the adult group (p = 0.041). The body mass index between groups with a decreased presentation of AIDS in the elderly group (p = 0.040) compared to the adult group. The relationship of color and biological sex with collagen, BMI and thickness of bone trabeculae, not clear clear difference. Conclusion: the AIDS factor influences the decrease in the thickness of the bone trabeculae and favors the increase in total collagen in adults and the elderly, being an important factor in the assessment of bone mass, especially in those aged over 50 years who present greater loss of organic matrix.