Efeitos dose-resposta do treinamento de força na qualidade de vida, composição corporal e marcadores inflamatórios em sobreviventes de câncer de mama

Abstract

Breast cancer survivors (BCS) often experience physiological and psychological challenges, including altered body composition, chronic inflammation, and reduced quality of life (QoL). Resistance training (RT) is a well-established rehabilitation strategy; however, optimal training volume remains unclear. Higher-volume RT (HVRT)—more than three sets per muscle group—has shown superior benefits in other populations. However, concerns about fatigue and adherence to training require investigation. This study examined the effects of RT volume on quality of life (QoL), inflammatory markers, and body composition in BCS women. Twenty-six BCS were randomly assigned to standard-volume RT (SVRT) (three sets per muscle group, n = 14) or higher-volume RT (HVRT) (six sets per muscle group, n = 12). Both groups performed 10 full-body exercises three times per week for 12 weeks. quality of life (QoL), body composition, and inflammatory markers were assessed pre- and post-intervention. Participants (37–73 years) were overweight with elevated waist-to-hip ratios. HVRT led to greater improvements than SVRT (P_interaction = 0.009), including a 9% increase in total quality of life (QoL) (mental health +8%, social +17%, emotional well-being +30.2%). Adiponectin increased 22% in HVRT but remained unchanged in SVRT (P_interaction = 0.035). Both groups gained muscle mass, reduced subcutaneous fat, and exhibited higher IL-6 levels (P_time < 0.05). Adiponectin increases correlated positively with quality of life (QoL) improvements. HVRT enhances quality of life (QoL) and adiponectin levels in BCS, particularly improving mental, social, and emotional well-being. These findings support tailored RT protocols to optimize BCS recovery.