Caracterização do bioativo natural paepalantina encapsulada em lipossomas unilamelares grandes - LUVs

Abstract

Bioactive compounds have garnered significant attention due to their wide range of biological activities and their applicability in the food, cosmetic, and pharmaceutical industries. Among these compounds, paepalantine stands out for its well-documented anti-inflammatory, antioxidant, and anticancer properties. However, its therapeutic potential is limited by unfavorable physicochemical characteristics, including low aqueous solubility, high susceptibility to environmental degradation, and reduced stability in the gastrointestinal tract factors that compromise its bioavailability and pharmaceutical applicability. To address these limitations, nanoencapsulation emerges as a promising strategy to enhance the stability and performance of paepalantine in biological systems. In this context, the present study aimed to characterize the interaction of paepalantine with liposomal systems, evaluating key physicochemical parameters essential for the development of nanoformulations. Spectrophotometric analyses revealed changes in the compound’s absorption profile following incorporation into lipid matrices, indicating a strong affinity for hydrophobic environments. Multilamellar liposomal formulations exhibited adequate stability, as demonstrated by hydrodynamic size and zeta potential measurements, reinforcing the feasibility of employing liposomal systems for paepalantine encapsulation. The results presented here expand current knowledge regarding the behavior of paepalantine in lipid systems and provide fundamental parameters for future nanoencapsulation approaches and the development of more efficient pharmaceutical formulations. This study contributes to the scientific understanding of paepalantine’s applicability and establishes a solid methodological foundation for subsequent investigations. Thus, it is possible to highlight that the characterization performed demonstrates the potential of paepalantine for the development of nanostructured systems applicable to the pharmaceutical field.