Alterações autonômicas e cronotrópicas cardíacas após a administração de esteróide anabólico androgênico associado ao treinamento físico

Abstract

This study aimed to evaluate the effect of chronic treatment with anabolic androgenic steroids associated to exercise training in cardiovascular autonomic control. Its evaluated on resting, heart rate, systolic and diastolic, vagal and sympathetic tone and effect, intrinsic cardiac pacemaker, baroreflex sensitivity, heart rate variability, blood pressure variability and cardiac mass. We used male Wistar rats weighing between 400g and 500g were divided into 6 groups: control (SC, n = 10), sedentary vehicle (SV, N = 10), sedentary DECA (SD N = 10), trained control (TC, N = 10) trained vehicle (TV N = 10) and trained DECA (TD N = 10). Statistical analyzes with significance p <0.05, and results expressed as mean±sem. The TD group animals showed lower body weight compared to SD, SV and SC groups had no change in this parameter. The groups TC, TV and TD decreased HR compared to SC, SV and SD, but no change of the BP. Vagal effect and vagal tone attenuated in SD compared to other groups in the study, the sympathetic effect was reduced in SD and TD. The sympathovagal index showed accentuation between SD and SC groups compared to SV, also vs TC, TV and TD, the TD group showed a decrease compared to SD, CT and TV. The intrinsic rate of cardiac pacemaker, showed an increase in SD, paired SC and SV, the SV group had attenuation compared to SC. The TC group showed accentuation and attenuation vs SV vs SD; elevation between TV vs SC, SV and TC, and TD group showed a decrease vs SD and TV. Reflex responses expressed decrease in SD compared to the other groups. The pulse interval was shown to be high in (TC, TV and TD) vs. (SC, SV and SD), and the components of heart rate variability, vagal and sympathetic, absolute and normalized, presented themselves reduced in the trained groups compared to sedentary groups. The LF component of DBPV, SD group increased, compared to the groups SC, TC and TV, the TC group showed a reduction in absolute LF vs SC, SV and SD, also compared to TV, the TD group animals showed elevation if compared to TC and TV, and a decrease when compared to the SV and SD groups. This component, analyzed in the frequency domain, showed a rise in SD, compared to SV and SC groups, and similarly to its absolute value, the trained groups (TC, TV and TD) showed reduced versus SD, TD has proved high compared to CT and TV. Analyzing SBPV, there were differences in variance between SD and TC; VLF band also changed between these two groups. Already the LF component showed absolute differences between SD compared to SC. The TC showed a group difference compared SV and TC, or TC and SD, SV and SD groups in the absolute LF component showed exacerbated the TC group. The relative heart weight showed an increase between group TD and SC, between TV and SD, as well as between TD, compared to SV, SD and TC. The results suggest that the administration of nandrolone decanoate at a dose of 5 mg / kg / week causes a decrease vagal activity and autonomic cardiovascular variations. However swimming physical training concomitant with this therapy prevented such dysfunctions.